Talking Product Videos have been used to promote ethical issues like the Environment, & Animal Welfare. They are a great way to support petitions & have high impact value. Imagine for instance a dog from a dog shelter, talking on video, asking to be homed. A great way to support on line petitions.

They can also be used by charities to attract donations & sponsors. Here are some samples:-

Clean Up Your Act

Gulf of Mexico Oil Spillage 

Stop Deforestation & Drilling of the Arctic